Reactome | PAK1 or PAK2 phosphorylates MYLK

Schema > Reaction > Entries

PAK1 or PAK2 phosphorylates MYLK Show undefined attributes

catalystActivity	[CatalystActivity:10059477] protein serine/threonine kinase activity of p-S,T-PAK1,2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10059479
displayName	PAK1 or PAK2 phosphorylates MYLK
eventOf	[Pathway:R-RNO-5627123] RHO GTPases activate PAKs - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5668984] PAK1 or PAK2 phosphorylates MYLK - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-RNO-445807] MYLK(1-1914) [cytosol]
isInDisease	false
isInferred	true
name	PAK1 or PAK2 phosphorylates MYLK
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-RNO-5668975] phospho-p-S1208,S1759-MYLK(1-1914) [cytosol]
precedingEvent	[Reaction:R-RNO-5627775] Autophosphorylation of PAK1,2,3 - Rattus norvegicus [Reaction:R-RNO-2029454] Autophosphorylation of PAK1 - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5668984
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5627123] RHO GTPases activate PAKs
(inferredTo)	[Reaction:R-HSA-5668984] PAK1 or PAK2 phosphorylates MYLK