Reactome | PTK2beta binds alphaVbeta3

Schema > Reaction > Entries

PTK2beta binds alphaVbeta3 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10052928
displayName	PTK2beta binds alphaVbeta3
eventOf	[Pathway:R-RNO-4420097] VEGFA-VEGFR2 Pathway - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5218830] SRC-1 phosphorylates PTK2-beta - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5218836] PTK2beta binds alphaVbeta3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-390932] PTK2B [cytosol] [Complex:R-RNO-5218779] VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane]
isInDisease	false
isInferred	true
name	PTK2beta binds alphaVbeta3
output	[Complex:R-RNO-5218787] VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2B [plasma membrane]
precedingEvent	[Reaction:R-RNO-5218818] Integrin alphaVbeta3 binds p-6Y-VEGFR2 - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5218836
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-RNO-5218830] SRC-1 phosphorylates PTK2-beta
(inferredTo)	[Reaction:R-HSA-5218836] PTK2beta binds alphaVbeta3