Reactome | PHLPP dephosphorylates S473 in AKT

Schema > Reaction > Entries

PHLPP dephosphorylates S473 in AKT Show undefined attributes

catalystActivity	[CatalystActivity:10001082] protein serine/threonine phosphatase activity of PHLPP (Mn2+ cofactor) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10001084
displayName	PHLPP dephosphorylates S473 in AKT
eventOf	[Pathway:R-RNO-199418] Negative regulation of the PI3K/AKT network - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:263612] negative regulation of protein kinase B signaling
inferredFrom	[Reaction:R-HSA-199425] PHLPP dephosphorylates S473 in AKT - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [CandidateSet:R-RNO-202074] p-T,p-S-AKT [cytosol]
isInDisease	false
isInferred	true
name	PHLPP dephosphorylates S473 in AKT
output	[CandidateSet:R-RNO-202084] p-T-AKT [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-199425
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-199418] Negative regulation of the PI3K/AKT network
(inferredTo)	[Reaction:R-HSA-199425] PHLPP dephosphorylates S473 in AKT