Reactome | Intrinsic Pathway of Fibrin Clot Formation

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Intrinsic Pathway of Fibrin Clot Formation Show undefined attributes

compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10095507
displayName	Intrinsic Pathway of Fibrin Clot Formation
eventOf	[Pathway:R-RNO-140877] Formation of Fibrin Clot (Clotting Cascade) - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23206] blood coagulation, intrinsic pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-158354] kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer - Rattus norvegicus [Reaction:R-RNO-158218] prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer - Rattus norvegicus [Reaction:R-RNO-158251] prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer - Rattus norvegicus [Reaction:R-RNO-158311] kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin - Rattus norvegicus [Reaction:R-RNO-158313] factor XII -> factor XIIa - Rattus norvegicus [Reaction:R-RNO-158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex - Rattus norvegicus [Reaction:R-RNO-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Rattus norvegicus [Reaction:R-RNO-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Rattus norvegicus [BlackBoxEvent:R-RNO-9670673] FIX is secreted - Rattus norvegicus [Reaction:R-RNO-158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) - Rattus norvegicus [BlackBoxEvent:R-RNO-9661625] FVIII is secreted - Rattus norvegicus [Reaction:R-RNO-9015379] Factor IIa inhibitors (compounds) binds IIa - Rattus norvegicus [Reaction:R-RNO-9603302] Factor IIa inhibitors (peptide) binds IIa - Rattus norvegicus [Reaction:R-RNO-5607043] factor VIIIa associates with cell membrane - Rattus norvegicus [Reaction:R-RNO-5607023] factor IXa associates with cell membrane - Rattus norvegicus [Reaction:R-RNO-158278] factor VIIIa + factor IXa -> factor VIIIa:factor IXa - Rattus norvegicus [Reaction:R-RNO-158164] factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) - Rattus norvegicus [Reaction:R-RNO-9670014] Factor VIIIa dissociates - Rattus norvegicus [BlackBoxEvent:R-RNO-9650473] SERPING1 is secreted - Rattus norvegicus [Reaction:R-RNO-158399] kallikrein binds SERPING1 - Rattus norvegicus [Reaction:R-RNO-158357] factor XIIa binds SERPING1 - Rattus norvegicus [Reaction:R-RNO-158340] kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-140837] Intrinsic Pathway of Fibrin Clot Formation - Homo sapiens
isInDisease	false
isInferred	true
name	Intrinsic Pathway of Fibrin Clot Formation Generation of intrinsic Factor X activating complex
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-140837
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-140877] Formation of Fibrin Clot (Clotting Cascade)
(inferredTo)	[Pathway:R-HSA-140837] Intrinsic Pathway of Fibrin Clot Formation

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