Reactome | cGAS ligands [cytosol]

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cGAS ligands [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-3244625] cGAS:dsDNA [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-3244647] cGAS binds cytosolic DNA - Homo sapiens
created	[InstanceEdit:8982070] Shamovsky, Veronica, 2017-03-15
dbId	8982071
disease	[Disease:3134794] viral infectious disease [Disease:3134792] bacterial infectious disease
displayName	cGAS ligands [cytosol]
goCellularComponent	[Compartment:436407] host cell cytosol
hasMember	[GenomeEncodedEntity:R-HER-8982066] HSV1 dsDNA [cytosol] - Human herpesvirus 1 [Complex:R-HIV-177535] viral DNA with 3' sticky ends [cytosol] - Human immunodeficiency virus 1 [GenomeEncodedEntity:R-MTU-8982063] M. tuberculosis dsDNA [cytosol] - Mycobacterium tuberculosis [GenomeEncodedEntity:R-LMO-8982051] L. monocytogenes dsDNA [cytosol] - Listeria monocytogenes
inDisease	true
literatureReference	[LiteratureReference:8982064] Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses [LiteratureReference:3244591] Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA [LiteratureReference:8982049] A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis [LiteratureReference:8982046] The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy [LiteratureReference:8982056] Listeria monocytogenes induces IFN? expression through an IFI16-, cGAS- and STING-dependent pathway
modified	[InstanceEdit:9773515] Weiser, Joel, 2022-05-04
name	cGAS ligands
schemaClass	DefinedSet
species	[Species:164493] Human immunodeficiency virus 1 [Species:176806] Mycobacterium tuberculosis [Species:5689680] Human herpesvirus 1 [Species:8875362] Listeria monocytogenes
stId	R-NUL-8982071

Referrals

(input)	[Reaction:R-HSA-3244647] cGAS binds cytosolic DNA
(hasComponent)	[Complex:R-HSA-3244625] cGAS:dsDNA [cytosol]

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