Reactome | Clock acetylates Bmal1 on lysine-544 (lysine-537 of isoform 2)

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Clock acetylates Bmal1 on lysine-544 (lysine-537 of isoform 2) Show undefined attributes

authored	[InstanceEdit:9920688] May, Bruce, 2024-08-15
catalystActivity	[CatalystActivity:9928710] protein-lysine-acetyltransferase activity of p-S97-Bmal1:p-T451,T461,S440,S441,S446-Clock:Per2 gene [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9920722] May, Bruce, 2024-09-03
dbId	9920709
displayName	Clock acetylates Bmal1 on lysine-544 (lysine-537 of isoform 2)
edited	[InstanceEdit:9920688] May, Bruce, 2024-08-15
input	[SimpleEntity:R-ALL-113560] Ac-CoA [nucleoplasm] [Complex:R-MMU-9928729] p-S97-Bmal1:p-T451,T461,S440,S441,S446-Clock:Per2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3697951] CLOCK-mediated acetylation of BMAL1 controls circadian function
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Clock acetylates Bmal1 on lysine-544 (lysine-537 of isoform 2)
orthologousEvent	[Reaction:R-HSA-9920716] CLOCK acetylates BMAL1 on lysine-538 - Homo sapiens
output	[SimpleEntity:R-ALL-2485002] CoA-SH [nucleoplasm] [Complex:R-MMU-9920675] p-S97,Ac-K544-Bmal1:p-T451,T461,S440,S441,S446-Clock:Per2 gene [nucleoplasm]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9920709
summation	[Summation:9930002] Clock in the Bmal1:Clock heterodimer acetylates lysine-544 o...

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