Reactome | Jak2, Tyk2 in Il12b:Il23a:Il12rb1:Tyk2:Il23r:Jak2 are phosphorylated

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:8950030] Duenas, Corina, 2016-12-02
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
dbId	8950612
displayName	Jak2, Tyk2 in Il12b:Il23a:Il12rb1:Tyk2:Il23r:Jak2 are phosphorylated
edited	[InstanceEdit:9006078] Duenas, Corina, 2017-05-12
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-8950324] Il12b:Il23a:Il12rb1:Tyk2:Il23r:Jak2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8950054] Defining the functional binding sites of interleukin 12 receptor ?1 and interleukin 23 receptor to Janus kinases
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Jak2, Tyk2 in Il12b:Il23a:Il12rb1:Tyk2:Il23r:Jak2 are phosphorylated Jak2 and Tyk2 activation after Il23:Il23r interaction
orthologousEvent	[BlackBoxEvent:R-HSA-8950591] JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated - Homo sapiens
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-8950690] Il12b:Il23a:Il12rb1:p-Y-Tyk2:Il23:p-Y-Jak2 [plasma membrane]
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-8950612
summation	[Summation:8950436] The intracellular domain of Interleukin-12 receptor beta 1 s...

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