Reactome | VLDLR internalisation and degradation

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VLDLR internalisation and degradation Show undefined attributes

created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9978702
displayName	VLDLR internalisation and degradation
eventOf	[Pathway:R-MMU-8964043] Plasma lipoprotein clearance - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262424] low-density lipoprotein particle receptor catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-8854628] MYLIP dimer ubiquitinates VLDLR on Lys-839 - Mus musculus [Reaction:R-MMU-8855111] VLDLR binds PCSK9 - Mus musculus [Reaction:R-MMU-8855131] VLDLR:PCSK9 binds Clathrin-coated vesicles - Mus musculus [BlackBoxEvent:R-MMU-8855130] VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane - Mus musculus
inferredFrom	[Pathway:R-HSA-8866427] VLDLR internalisation and degradation - Homo sapiens
isInDisease	false
isInferred	true
name	VLDLR internalisation and degradation
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-8866427
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8964043] Plasma lipoprotein clearance
(inferredTo)	[Pathway:R-HSA-8866427] VLDLR internalisation and degradation

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