Reactome | ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate

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ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate Show undefined attributes

catalystActivity	[CatalystActivity:9866021] 1-pyrroline-5-carboxylate dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9946446
displayName	ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate
eventOf	[Pathway:R-MMU-389661] Glyoxylate metabolism and glycine degradation - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:15010] glyoxylate metabolic process
inferredFrom	[Reaction:R-HSA-6784399] ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate - Homo sapiens
input	[SimpleEntity:R-ALL-6784223] 4-OH-L-Glu semialdehyde [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate 4-OH-L-glutamate semialdehyde + NAD+ => 4-OH-L-glutamate + HADH + H+
output	[SimpleEntity:R-ALL-6784236] 4-OH-L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6784399
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-389661] Glyoxylate metabolism and glycine degradation
(precedingEvent)	[Reaction:R-MMU-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)
(inferredTo)	[Reaction:R-HSA-6784399] ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate

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