Reactome | AACS ligates CoA-SH to ACA, forming ACA-CoA

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AACS ligates CoA-SH to ACA, forming ACA-CoA Show undefined attributes

catalystActivity	[CatalystActivity:9945037] acetoacetate-CoA ligase activity of AACS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9945039
displayName	AACS ligates CoA-SH to ACA, forming ACA-CoA
eventOf	[Pathway:R-MMU-77111] Synthesis of Ketone Bodies - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5694494] AACS ligates CoA-SH to ACA, forming ACA-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-29666] ACA [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
isInDisease	false
isInferred	true
name	AACS ligates CoA-SH to ACA, forming ACA-CoA
output	[SimpleEntity:R-ALL-191293] ACA-CoA [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-MMU-5696457] BDH2 dehydrogenates 3HBA - Mus musculus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5694494
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-77111] Synthesis of Ketone Bodies
(inferredTo)	[Reaction:R-HSA-5694494] AACS ligates CoA-SH to ACA, forming ACA-CoA