Reactome | KALRN exchanges GTP for GDP on RAC1, activating it

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KALRN exchanges GTP for GDP on RAC1, activating it Show undefined attributes

catalystActivity	[CatalystActivity:9930924] guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:KALRN [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9930926
displayName	KALRN exchanges GTP for GDP on RAC1, activating it
eventOf	[Pathway:R-MMU-3928662] EPHB-mediated forward signaling - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-3928619] PAK1 binds RAC1:GTP - Mus musculus
inferredFrom	[Reaction:R-HSA-3928612] KALRN exchanges GTP for GDP on RAC1, activating it - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-MMU-217287] RAC1:GDP [plasma membrane]
isInDisease	false
isInferred	true
name	KALRN exchanges GTP for GDP on RAC1, activating it
output	[SimpleEntity:R-ALL-114549] GDP [plasma membrane] [Complex:R-MMU-217289] RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-MMU-3928617] EPHB2 binds KALRN - Mus musculus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-3928612
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-3928662] EPHB-mediated forward signaling
(precedingEvent)	[Reaction:R-MMU-3928619] PAK1 binds RAC1:GTP
(inferredTo)	[Reaction:R-HSA-3928612] KALRN exchanges GTP for GDP on RAC1, activating it

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