Reactome | ABL phosphorylates WAVEs

Schema > Reaction > Entries

ABL phosphorylates WAVEs Show undefined attributes

catalystActivity	[CatalystActivity:9922362] protein tyrosine kinase activity of ABL1 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9922364
displayName	ABL phosphorylates WAVEs
eventOf	[Pathway:R-MMU-5663213] RHO GTPases Activate WASPs and WAVEs - Mus musculus [Pathway:R-MMU-2029482] Regulation of actin dynamics for phagocytic cup formation - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2029469] p-ERK phosphorylates WAVEs and ABI - Mus musculus
inferredFrom	[Reaction:R-HSA-2130194] ABL phosphorylates WAVEs - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-2029147] WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane]
isInDisease	false
isInferred	true
name	ABL phosphorylates WAVEs
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-2130182] p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-MMU-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Mus musculus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2130194
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5663213] RHO GTPases Activate WASPs and WAVEs [Pathway:R-MMU-2029482] Regulation of actin dynamics for phagocytic cup formation
(precedingEvent)	[Reaction:R-MMU-2029469] p-ERK phosphorylates WAVEs and ABI
(inferredTo)	[Reaction:R-HSA-2130194] ABL phosphorylates WAVEs