Reactome | PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane

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PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane Show undefined attributes

catalystActivity	[CatalystActivity:9917110] phosphatidylinositol phospholipase C activity of PL(C)D4:3xCa2+ [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9917112
displayName	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
eventOf	[Pathway:R-MMU-1855204] Synthesis of IP3 and IP4 in the cytosol - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1855174] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol - Mus musculus [Reaction:R-MMU-1855222] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane - Mus musculus [Reaction:R-MMU-1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol - Mus musculus
inferredFrom	[Reaction:R-HSA-1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-2023856] PI(4,5)P2 [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
name	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
output	[SimpleEntity:R-ALL-1500596] DAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1855214
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1855204] Synthesis of IP3 and IP4 in the cytosol
(precedingEvent)	[Reaction:R-MMU-1855174] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol [Reaction:R-MMU-1855222] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane [Reaction:R-MMU-1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
(inferredTo)	[Reaction:R-HSA-1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane