Reactome | Synthesis of PC

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Synthesis of PC Show undefined attributes

created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9977162
displayName	Synthesis of PC
eventOf	[Pathway:R-MMU-1483206] Glycerophospholipid biosynthesis - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20466] phosphatidylcholine biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-1483174] PE is methylated to PC by PEMT - Mus musculus [BlackBoxEvent:R-MMU-8873794] PCTP binds PC - Mus musculus [Reaction:R-MMU-8877153] STARD7 binds PC - Mus musculus [Reaction:R-MMU-8873923] STARD10 binds LPCAT1 and PC - Mus musculus [BlackBoxEvent:R-MMU-8873834] STARD10 transports PC from ER membrane to lamellar body membrane - Mus musculus [Reaction:R-MMU-8873929] Casein kinase II phosphorylates STARD10 - Mus musculus [Reaction:R-MMU-444433] Cho transports from the extracellular space to the cytosol - Mus musculus [Reaction:R-MMU-1483004] Cho is phosphorylated to PCho by CHK dimer - Mus musculus [Reaction:R-MMU-1483159] PCho is dephosphorylated to Cho by PHOSPHO1 - Mus musculus [Reaction:R-MMU-264622] Cho is acetylated to AcCho by CHAT - Mus musculus [Reaction:R-MMU-1483081] PCho and CTP are condensed to CDP-Cho by PCYT1 dimer - Mus musculus [Reaction:R-MMU-1483203] PA is dephosphorylated to DAG by LPIN - Mus musculus [Reaction:R-MMU-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Mus musculus [Reaction:R-MMU-1482973] CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane - Mus musculus [Reaction:R-MMU-5694485] ABHD3 hydrolyses LPC(14:0) to 1AGPC - Mus musculus [Reaction:R-MMU-8865637] MFSD2A transports LPC from extracellular region to plasma membrane - Mus musculus
inferredFrom	[Pathway:R-HSA-1483191] Synthesis of PC - Homo sapiens
isInDisease	false
isInferred	true
name	Synthesis of PC
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-1483191
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1483206] Glycerophospholipid biosynthesis
(inferredTo)	[Pathway:R-HSA-1483191] Synthesis of PC

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