Reactome | inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate

Schema > Reaction > Entries

inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate Show undefined attributes

catalystActivity	[CatalystActivity:111493] adenylosuccinate synthase activity of Adenylosuccinate synthetase holoenzyme dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111475] D'Eustachio, P, 2004-02-18 17:36:00
dbId	111519
displayName	inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-29602] IMP [cytosol] [SimpleEntity:R-ALL-29448] L-Asp [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111503] Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance [LiteratureReference:111509] Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
orthologousEvent	[Reaction:R-GGA-421201] inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate - Gallus gallus
output	[SimpleEntity:R-ALL-35141] ADS [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
regulatedBy	[NegativeRegulation:R-MMU-111520] Negative regulation by 'ADS [cytosol]' [NegativeRegulation:R-MMU-111521] Negative regulation by 'guanosine 5'-monophosphate [cytosol]' [NegativeRegulation:R-MMU-111522] Negative regulation by 'GDP [cytosol]' [NegativeRegulation:R-MMU-111523] Negative regulation by 'D-Fructose 1,6-bisphosphate [cytosol]' [NegativeRegulation:R-MMU-111539] Negative regulation by 'adenosine 5'-monophosphate [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-111519
summation	[Summation:178894] Cytosolic ADSS dimer catalyzes the reaction of inosine 5'-mo...

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