Reactome | Loss of Function of TP53 in Cancer

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Loss of Function of TP53 in Cancer Show undefined attributes

authored	[InstanceEdit:9726526] Orlic-Milacic, Marija, 2021-04-07
created	[InstanceEdit:9723904] Orlic-Milacic, Marija, 2021-03-18
dbId	9723907
disease	[Disease:1500689] cancer
displayName	Loss of Function of TP53 in Cancer
doi	10.3180/R-HSA-9723907.1
edited	[InstanceEdit:9729597] Orlic-Milacic, Marija, 2021-05-03
eventOf	[Pathway:R-HSA-9734009] Defective Intrinsic Pathway for Apoptosis - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9723905] Loss of function of TP53 in cancer due to loss of tetramerization ability - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9726091] The p53 network: cellular and systemic DNA damage responses in aging and cancer [LiteratureReference:9726084] Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter? [LiteratureReference:9726088] Cancer. p53, guardian of the genome [LiteratureReference:9726103] p53 mutants without a functional tetramerisation domain are not oncogenic [LiteratureReference:9726109] The role of tetramerization in p53 function [LiteratureReference:9726113] Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus [LiteratureReference:6804858] p53 oligomerization and DNA looping are linked with transcriptional activation [LiteratureReference:9726354] p53 tetramerization: at the center of the dominant-negative effect of mutant p53 [LiteratureReference:9729595] Tetramer formation of tumor suppressor protein p53: Structure, function, and applications
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Loss of Function of TP53 in Cancer
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729599] Sakaguchi, Kazuyasu, 2021-04-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9723907
summation	[Summation:9726371] TP53 is the most frequently mutated tumor suppressor gene, w...

Referrals

(hasEvent)

[Pathway:R-HSA-9734009] Defective Intrinsic Pathway for Apoptosis