Reactome | HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9712031] HIP1(1-719)InsL-p-7Y ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9711957] Rothfels, Karen, 2021-01-13
crossReference	[DatabaseIdentifier:9711747] COSMIC:COSF1615
dbId	9711965
disease	[Disease:8853117] lung adenocarcinoma
displayName	HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol]
endCoordinate	719
hasModifiedResidue	[FragmentInsertionModification:9711913] Insertion of residues 1059 to 1620 at 720 from UniProt:Q9UM73 ALK [FragmentReplacedModification:9711923] Replacement of residues 719 to 719 by DL [ModifiedResidue:9699796] O4'-phospho-L-tyrosine at 1096 [ModifiedResidue:9699868] O4'-phospho-L-tyrosine at 1278 [ModifiedResidue:9699844] O4'-phospho-L-tyrosine at 1282 [ModifiedResidue:9699911] O4'-phospho-L-tyrosine at 1283 [ModifiedResidue:9699876] O4'-phospho-L-tyrosine at 1358 [ModifiedResidue:9699886] O4'-phospho-L-tyrosine at 1507 [ModifiedResidue:9699803] O4'-phospho-L-tyrosine at 1604
inDisease	true
literatureReference	[LiteratureReference:9711859] HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma
modified	[InstanceEdit:9832327] Orlic-Milacic, Marija, 2023-03-30
name	HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion Huntingtin-interacting protein 1 HIP1_HUMAN
referenceEntity	[ReferenceGeneProduct:56526] UniProt:O00291 HIP1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9711965
startCoordinate	1

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