Reactome | CBL R420G [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9706201] Rothfels, Karen, 2020-11-04
crossReference	[DatabaseIdentifier:9706202] COSMIC:COSV50630874 [DatabaseIdentifier:9706200] COSMIC:COSM34132
dbId	9706203
disease	[Disease:9630839] acute myeloid leukemia
displayName	CBL R420G [cytosol]
endCoordinate	906
hasModifiedResidue	[ReplacedResidue:9706034] L-arginine 420 replaced with glycine
inDisease	true
literatureReference	[LiteratureReference:9706063] CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes
memberOf	[CandidateSet:R-HSA-9706222] CBL mutants [cytosol] - Homo sapiens
name	CBL R420G CBL E3 ubiquitin protein ligase Signal transduction protein CBL Proto-oncogene c-CBL Casitas B-lineage lymphoma proto-oncogene
referenceEntity	[ReferenceGeneProduct:51488] UniProt:P22681 CBL
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9706203
startCoordinate	1

(hasMember)

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