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Schema
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Entries
quizartinib-resistant FLT3 mutants don't bind quizartinib
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authored
[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9702617] Rothfels, Karen, 2020-10-01
dbId
9702618
disease
[Disease:1500689] cancer
displayName
quizartinib-resistant FLT3 mutants don't bind quizartinib
edited
[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
entityFunctionalStatus
[EntityFunctionalStatus:9702619] loss_of_function of quizartinib-resistant FLT3 mutants [plasma membrane]
eventOf
[Pathway:R-HSA-9702620] quizartinib-resistant FLT3 mutants - Homo sapiens
input
[ChemicalDrug:R-ALL-9674318] quizartinib [cytosol]
[DefinedSet:R-HSA-9699525] quizartinib-resistant FLT3 mutants [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9699384] The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib
[LiteratureReference:9699271] Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia
[LiteratureReference:9699248] Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants
[LiteratureReference:9699359] Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns
[LiteratureReference:9702954] FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
quizartinib-resistant FLT3 mutants don't bind quizartinib
normalReaction
[Reaction:R-HSA-9695831] FLT3 binds type II TKI
releaseDate
2020-12-08
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9702618
summation
[Summation:9702942] The following FLT3 mutants are resistant to quizartinib (als...
Referrals
(hasEvent)
[Pathway:R-HSA-9702620] quizartinib-resistant FLT3 mutants
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