Reactome | Protease binds protease inhibitors

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Protease binds protease inhibitors Show undefined attributes

authored	[InstanceEdit:9684432] Jassal, Bijay, 2020-04-21
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9697044] Jassal, Bijay, 2020-08-05
dbId	9697043
definition	Inhibition
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Protease binds protease inhibitors
edited	[InstanceEdit:9684432] Jassal, Bijay, 2020-04-21
eventOf	[Pathway:R-HSA-162588] Budding and maturation of HIV virion - Homo sapiens
input	[EntityWithAccessionedSequence:R-HIV-3139031] GAG-POL Polyprotein (P04585) [extracellular region] [DefinedSet:R-ALL-9684426] Protease inhibitors [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9680903] A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19 [LiteratureReference:9680871] Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study [LiteratureReference:9680876] Compounds with therapeutic potential against novel respiratory 2019 coronavirus [LiteratureReference:9680873] Coronavirus puts drug repurposing on the fast track [LiteratureReference:9681048] TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates [LiteratureReference:9681049] Activity of human immunodeficiency virus type 1 protease inhibitors against the initial autocleavage in Gag-Pol polyprotein processing [LiteratureReference:9684417] Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Protease binds protease inhibitors gag-pol(489-587) binds protease inhibitors
output	[Complex:R-HIV-9684421] Protease:Protease inhibitors [extracellular region]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9697043
summation	[Summation:9684414] Antiretroviral (ARV) therapy, comprising a backbone of two n...

Referrals

(hasEvent)

[Pathway:R-HSA-162588] Budding and maturation of HIV virion