Reactome | FLT3 F691L [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9695762] FLT3 F691L dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9695711] Rothfels, Karen, 2020-07-15
crossReference	[DatabaseIdentifier:9695684] COSMIC:COSV54050694
dbId	9695722
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 F691L [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9682371] L-phenylalanine 691 replaced with L-leucine
inDisease	true
literatureReference	[LiteratureReference:9695666] MZH29 is a novel potent inhibitor that overcomes drug resistance FLT3 mutations in acute myeloid leukemia
memberOf	[DefinedSet:R-HSA-9699541] pexidartinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699528] sunitinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699530] sorafenib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699525] quizartinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane] - Homo sapiens
name	FLT3 F691L STK-1
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9695722
startCoordinate	27

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