Reactome | p-6Y FLT3 K663Q [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9691995] p-6Y FLT3 K663Q dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9691934] Rothfels, Karen, 2020-06-19
crossReference	[DatabaseIdentifier:9691862] COSMIC:COSV54065828
dbId	9691942
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia [Disease:2317476] acute lymphocytic leukemia
displayName	p-6Y FLT3 K663Q [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9691887] L-lysine 663 replaced with L-glutamine [ModifiedResidue:9604760] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:9604750] O4'-phospho-L-tyrosine at 591 [ModifiedResidue:9604772] O4'-phospho-L-tyrosine at 599 [ModifiedResidue:9604762] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:9604765] O4'-phospho-L-tyrosine at 955 [ModifiedResidue:9604743] O4'-phospho-L-tyrosine at 969
inDisease	true
literatureReference	[LiteratureReference:9691860] FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248)
modified	[InstanceEdit:9699473] Rothfels, Karen, 2020-09-14
name	p-6Y FLT3 K663Q STK-1
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9691942
startCoordinate	27

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