Reactome | p-6Y-FLT3 Y597_E598insDEYFYVDFREY [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9691966] p-6Y FLT3 Y597_E598insDEYFYVDFREY dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9691934] Rothfels, Karen, 2020-06-19
dbId	9691936
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	p-6Y-FLT3 Y597_E598insDEYFYVDFREY [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentReplacedModification:9690080] Replacement of residues 597 to 598 by YDEYFYVDFREYE [ModifiedResidue:9604760] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:9604750] O4'-phospho-L-tyrosine at 591 [ModifiedResidue:9604772] O4'-phospho-L-tyrosine at 599 [ModifiedResidue:9604762] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:9604765] O4'-phospho-L-tyrosine at 955 [ModifiedResidue:9604743] O4'-phospho-L-tyrosine at 969
inDisease	true
literatureReference	[LiteratureReference:9683350] Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
modified	[InstanceEdit:9832492] Orlic-Milacic, Marija, 2023-04-01
name	p-6Y-FLT3 Y597_E598insDEYFYVDFREY STK-1 Mt5
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9691936
startCoordinate	27

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