Reactome | CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1

Schema > BlackBoxEvent > Entries

CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 Show undefined attributes

authored	[InstanceEdit:9674554] May, Bruce, 2020-01-11
category	uncertain
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9674559] May, Bruce, 2020-01-15
dbId	9674546
displayName	CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1
edited	[InstanceEdit:9674554] May, Bruce, 2020-01-11
eventOf	[Pathway:R-HSA-9674555] Signaling by CSF3 (G-CSF) - Homo sapiens
followingEvent	[Reaction:R-HSA-9674558] p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9674900] Csf3:Csf3r induces phosphorylation of Jak1 - Mus musculus
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9677578] CSF3 dimer:2xCSF3R:LYN:JAK1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9674549] Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation [LiteratureReference:9674969] Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor [LiteratureReference:9674893] Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor [LiteratureReference:9674947] The granulocyte colony stimulating factor (G-CSF) activates Jak/STAT and MAPK pathways in a trophoblastic cell line [LiteratureReference:9674566] Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9674580] CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9677585] CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9674546
summation	[Summation:9677133] JAK1 is phosphorylated by an unknown kinase in response to C...

Referrals

(precedingEvent)	[Reaction:R-HSA-9674558] p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1
(hasEvent)	[Pathway:R-HSA-9674555] Signaling by CSF3 (G-CSF)
(inferredTo)	[BlackBoxEvent:R-MMU-9674900] Csf3:Csf3r induces phosphorylation of Jak1