Reactome | F8(392-759) D579A [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9668368] Shamovsky, Veronica, 2019-11-25
dbId	9668364
disease	[Disease:9661959] factor VIII deficiency
displayName	F8(392-759) D579A [plasma membrane]
endCoordinate	759
hasModifiedResidue	[ReplacedResidue:9668350] L-aspartic acid 579 replaced with L-alanine
inDisease	true
literatureReference	[LiteratureReference:9668349] Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex
memberOf	[DefinedSet:R-HSA-9668369] F8(373-640) variant [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9670077] Shamovsky, Veronica, 2019-12-04
name	F8(392-759) D579A FVIIIa D579A A2 polypeptide F8 D579A A2 polypeptide
referenceEntity	[ReferenceGeneProduct:54602] UniProt:P00451 F8
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9668364
startCoordinate	392

(hasMember)

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