Reactome | ERBB2 V659E [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
crossReference	[DatabaseIdentifier:9667215] COSMIC:COSV54062460 [DatabaseIdentifier:9667216] COSMIC:COSV54065138
dbId	9665752
disease	[Disease:1500689] cancer [Disease:2327989] bile duct carcinoma [Disease:8853117] lung adenocarcinoma [Disease:1247848] non-small cell lung carcinoma
displayName	ERBB2 V659E [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9665762] L-valine 659 replaced with L-glutamic acid
inDisease	true
literatureReference	[LiteratureReference:9666001] Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
memberOf	[DefinedSet:R-HSA-9665964] ERBB2 TMD/JMD mutants (pertuzumab resistant) [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9665934] ERBB2 TMD/JMD mutants (neratinib) [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9665955] ERBB2 TMD/JMD mutants (trastuzumab) [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9667217] Orlic-Milacic, Marija, 2019-11-08
name	ERBB2 V659E
referenceEntity	[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9665752
startCoordinate	23

(hasMember)	[DefinedSet:R-HSA-9665964] ERBB2 TMD/JMD mutants (pertuzumab resistant) [plasma membrane] [DefinedSet:R-HSA-9665934] ERBB2 TMD/JMD mutants (neratinib) [plasma membrane] [DefinedSet:R-HSA-9665955] ERBB2 TMD/JMD mutants (trastuzumab) [plasma membrane]
(hasCandidate)	[CandidateSet:R-HSA-9665885] ERBB2 TMD/JMD mutants [plasma membrane]