Reactome | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects

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authored	[InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07
created	[InstanceEdit:9659788] Orlic-Milacic, Marija, 2019-09-05
dbId	9659787
disease	[Disease:1500689] cancer
displayName	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
edited	[InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18
eventOf	[Pathway:R-HSA-9687139] Aberrant regulation of mitotic cell cycle due to RB1 defects - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9661070] Defective translocation of RB1 mutants to the nucleus - Homo sapiens [Pathway:R-HSA-9661069] Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9661157] Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts? [LiteratureReference:9661125] The retinoblastoma tumour suppressor in development and cancer
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9659787
summation	[Summation:9661088] RB1 protein, also known as pRB or retinoblastoma protein, is...

(hasEvent)

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