Reactome | Defective OGG1 mutants do not excise FapyG

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Defective OGG1 mutants do not excise FapyG Show undefined attributes

authored	[InstanceEdit:9656251] Orlic-Milacic, Marija, 2019-07-30
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9656251] Orlic-Milacic, Marija, 2019-07-30
dbId	9656252
disease	[Disease:1500689] cancer
displayName	Defective OGG1 mutants do not excise FapyG
edited	[InstanceEdit:9663704] Orlic-Milacic, Marija, 2019-10-10
entityFunctionalStatus	[EntityFunctionalStatus:9657141] partial_loss_of_function of OGG1 mutants:FapyG-dsDNA [nucleoplasm]
eventOf	[Pathway:R-HSA-9656256] Defective OGG1 Substrate Processing - Homo sapiens
input	[Complex:R-HSA-9657134] OGG1 mutants:FapyG-dsDNA [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9657125] Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein [LiteratureReference:9658807] Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective OGG1 mutants do not excise FapyG
normalReaction	[Reaction:R-HSA-110244] Excision of FapyG by OGG1 glycosylase
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9663702] Vlahopoulos, Spiros, 2019-10-02 [InstanceEdit:9663703] Boldogh, Istvan, 2019-10-08
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9656252
summation	[Summation:9657136] OGG1 R46Q mutant, reported in renal carcinoma, and OGG1 R154...

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[Pathway:R-HSA-9656256] Defective OGG1 Substrate Processing

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