Reactome | p-6Y-ERBB2 G778_P780dup [plasma membrane]

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p-6Y-ERBB2 G778_P780dup [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9647197] Orlic-Milacic, Marija, 2019-05-30
crossReference	[DatabaseIdentifier:9646666] COSMIC:COSV54065275 [DatabaseIdentifier:9646673] COSMIC:COSM21607 [DatabaseIdentifier:9646671] COSMIC:COSV54064411
dbId	9647198
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1500699] lung cancer
displayName	p-6Y-ERBB2 G778_P780dup [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[FragmentInsertionModification:9646668] Insertion of residues 778 to 780 at 781 from UniProt:P04626 ERBB2 [ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023 [ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139 [ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196 [ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221 [ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222 [ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
inDisease	true
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
memberOf	[CandidateSet:R-HSA-9664612] p-6Y-ERBB2 KD mutants (EGFR) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9664920] p-6Y-ERBB2 KD mutants (EGFR,PI3K) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9665035] p-6Y-ERBB2 KD mutants (EGFR,PLCG1) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9831084] Orlic-Milacic, Marija, 2023-03-18
name	p-6Y-ERBB2 G778_P780dup p-6Y-HER2 G778_P780dup
referenceEntity	[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9647198
startCoordinate	23

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