Reactome | ERBB2 L755P [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

ERBB2 L755P [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9646498] Orlic-Milacic, Marija, 2019-05-24
crossReference	[DatabaseIdentifier:9646496] COSMIC:COSV54069116 [DatabaseIdentifier:9646524] COSMIC:COSM6907352
dbId	9646494
disease	[Disease:1500689] cancer [Disease:1500699] lung cancer
displayName	ERBB2 L755P [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646492] L-leucine 755 replaced with L-proline
inDisease	true
literatureReference	[LiteratureReference:9646493] Atomistic insights into the lung cancer-associated L755P mutation in HER2 resistance to lapatinib: a molecular dynamics study
memberOf	[CandidateSet:R-HSA-9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9665271] ERBB2 KD mutants (AEE788 resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9665282] ERBB2 KD mutants (lapatinib resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9664578] ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9646539] Orlic-Milacic, Marija, 2019-05-24
name	ERBB2 L755P HER2 L755P ERBB2 Leu755Pro HER2 Leu755Pro
referenceEntity	[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9646494
startCoordinate	23

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