Reactome | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects

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Evasion of Oncogene Induced Senescence Due to p16INK4A Defects Show undefined attributes

authored	[InstanceEdit:9632937] Orlic-Milacic, Marija, 2018-12-24
created	[InstanceEdit:9630751] Orlic-Milacic, Marija, 2018-12-03
dbId	9630750
disease	[Disease:1500689] cancer
displayName	Evasion of Oncogene Induced Senescence Due to p16INK4A Defects
doi	10.3180/R-HSA-9630750.2
edited	[InstanceEdit:9645275] Orlic-Milacic, Marija, 2019-05-07
eventOf	[Pathway:R-HSA-9630747] Diseases of Cellular Senescence - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9630794] Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 - Homo sapiens [Pathway:R-HSA-9630791] Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9632080] p16INK4a-induced senescence is disabled by melanoma-associated mutations [LiteratureReference:9632933] Evasion of Cell Senescence Leads to Medulloblastoma Progression [LiteratureReference:9633900] The molecular balancing act of p16(INK4a) in cancer and aging [LiteratureReference:9633902] Forging a signature of in vivo senescence [LiteratureReference:9633904] Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review [LiteratureReference:9633943] Parallel pathways in RAF-induced senescence and conditions for its reversion [LiteratureReference:9634009] p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas [LiteratureReference:9634000] 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers [LiteratureReference:9633989] Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing [LiteratureReference:9634012] Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers [LiteratureReference:9634134] Tumor suppression by ARF: gatekeeper and caretaker [LiteratureReference:9634098] Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53 [LiteratureReference:9634089] Mitochondrial p32 is a critical mediator of ARF-induced apoptosis [LiteratureReference:9634125] Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma [LiteratureReference:9634122] Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas [LiteratureReference:9634106] INK4a/ARF locus alterations in human non-Hodgkin's lymphomas mainly occur in tumors with wild-type p53 gene [LiteratureReference:9634123] INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53 [LiteratureReference:9634101] Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis [LiteratureReference:9645245] Detection of Oncogene-Induced Senescence In Vivo [LiteratureReference:9632507] Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information [LiteratureReference:9634003] The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments [LiteratureReference:9649094] A deep intronic mutation in CDKN2A is associated with disease in a subset of melanoma pedigrees [LiteratureReference:9649105] Intronic sequence variants of the CDKN2A gene in melanoma pedigrees [LiteratureReference:9649190] Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma [LiteratureReference:9649181] Mutation analysis of the CDKN2A promoter in Australian melanoma families [LiteratureReference:9632578] CDKN2A/p16 is inactivated in most melanoma cell lines [LiteratureReference:9649202] A cell cycle regulator potentially involved in genesis of many tumor types [LiteratureReference:9649199] Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Evasion of Oncogene Induced Senescence Due to p16INK4A Defects
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9645278] Bennett, Dorothy C, 2019-04-23 [InstanceEdit:9649238] Nathan, Vaishnavi, 2019-06-03 [InstanceEdit:9649237] Hayward, Nicholas K, 2019-06-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9630750
summation	[Summation:9630755] The CDKN2A gene consists of four exons, exon 1beta, exon 1al...

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[Pathway:R-HSA-9630747] Diseases of Cellular Senescence

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