Reactome | NEIL1 G83D does not cleave DHU

Schema > FailedReaction > Entries

authored	[InstanceEdit:9629972] Orlic-Milacic, Marija, 2018-11-26
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9628739] Orlic-Milacic, Marija, 2018-11-12
dbId	9628737
disease	[Disease:1500689] cancer
displayName	NEIL1 G83D does not cleave DHU
edited	[InstanceEdit:9634081] Orlic-Milacic, Marija, 2019-01-04
entityFunctionalStatus	[EntityFunctionalStatus:9628754] loss_of_function of NEIL1 G83D:DHU-dsDNA [nucleoplasm]
eventOf	[Pathway:R-HSA-9616334] Defective Base Excision Repair Associated with NEIL1 - Homo sapiens
input	[Complex:R-HSA-9628740] NEIL1 G83D:DHU-dsDNA [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9628747] Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NEIL1 G83D does not cleave DHU
normalReaction	[Reaction:R-HSA-5649658] NEIL1 cleaves DHU from damaged DNA
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9634078] Sampath, Harini, 2019-01-03
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9628737
summation	[Summation:9628741] NEIL1 G83D variant is a low frequency polymorphism, estimate...

(hasEvent)

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