Reactome | SREBF1 gene expression is inhibited by FOXO1

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9625975] Orlic-Milacic, Marija, 2018-10-23
category	omitted
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:9625350] Orlic-Milacic, Marija, 2018-10-19
dbId	9625346
displayName	SREBF1 gene expression is inhibited by FOXO1
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-9615017] FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes - Homo sapiens
inferredFrom	[BlackBoxEvent:R-NUL-9625366] Srebf1 gene expression is inhibited by FOXO1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5641206] SREBF1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SREBF1 gene expression is inhibited by FOXO1
output	[EntityWithAccessionedSequence:R-HSA-1368141] SREBF1(1-1147) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9625324] FOXO1 binds SREBF1 gene promoter - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:9625364] Negative gene expression regulation by 'FOXO1:SREBF1 gene [nucleoplasm]'
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9626980] Donlon, Timothy, 2018-10-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9625346
summation	[Summation:9625349] FOXO1 directly represses transcription of the SREBF1 (SREBP1...

(hasEvent)	[Pathway:R-HSA-9615017] FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
(inferredTo)	[BlackBoxEvent:R-NUL-9625366] Srebf1 gene expression is inhibited by FOXO1

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