Reactome | Loss of phosphorylation of MECP2 at T308

Schema > Pathway > Entries

authored	[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9022536] Orlic-Milacic, Marija, 2017-09-25
crossReference	[DatabaseIdentifier:12325464] BioModels Database:BIOMD0000000467 [DatabaseIdentifier:12325396] BioModels Database:BIOMD0000000088 [DatabaseIdentifier:12325480] BioModels Database:BIOMD0000000468
dbId	9022535
disease	[Disease:9005548] Rett syndrome
displayName	Loss of phosphorylation of MECP2 at T308
edited	[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
eventOf	[Pathway:R-HSA-9005891] Loss of function of MECP2 in Rett syndrome - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9005561] Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308 - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8986952] Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Loss of phosphorylation of MECP2 at T308
normalPathway	[Pathway:R-HSA-8986944] Transcriptional Regulation by MECP2
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07 [InstanceEdit:9608114] Christodoulou, John, 2018-08-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9022535
summation	[Summation:9024238] Missense mutations of methyl-CpG-binding protein 2 (MECP2) i...

(hasEvent)

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