Reactome | RAC3 GAPs stimulate RAC3 GTPase activity

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RAC3 GAPs stimulate RAC3 GTPase activity Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695561] Rothfels, Karen, 2020-07-14
catalystActivity	[CatalystActivity:9020406] GTPase activator activity of RAC3 GAPs [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9018805] Orlic-Milacic, Marija, 2017-09-05
dbId	9018806
displayName	RAC3 GAPs stimulate RAC3 GTPase activity
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-9013423] RAC3 GTPase cycle - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-9020388] RAC3:GTP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9692321] Characterization of RAC3, a novel member of the Rho family [LiteratureReference:9692317] Inhibitory effects of Arhgap6 on cervical carcinoma cells [LiteratureReference:9679344] Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms [LiteratureReference:9679631] Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS [LiteratureReference:8871052] A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway [LiteratureReference:9681483] The effect of missense mutations in the RhoGAP-homology domain on ocrl1 function [LiteratureReference:9690835] Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	RAC3 GAPs stimulate RAC3 GTPase activity
orthologousEvent	[Reaction:R-DDI-9018806] RAC3 GAPs stimulate RAC3 GTPase activity - Dictyostelium discoideum [Reaction:R-CEL-9018806] RAC3 GAPs stimulate RAC3 GTPase activity - Caenorhabditis elegans [Reaction:R-DME-9018806] RAC3 GAPs stimulate RAC3 GTPase activity - Drosophila melanogaster [Reaction:R-GGA-9018806] RAC3 GAPs stimulate RAC3 GTPase activity - Gallus gallus [Reaction:R-XTR-9018806] RAC3 GAPs stimulate RAC3 GTPase activity - Xenopus tropicalis [Reaction:R-DRE-9018806] RAC3 GAPs stimulate RAC3 GTPase activity - Danio rerio [Reaction:R-SSC-9018806] RAC3 GAPs stimulate RAC3 GTPase activity - Sus scrofa [Reaction:R-BTA-9018806] RAC3 GAPs stimulate RAC3 GTPase activity - Bos taurus [Reaction:R-CFA-9018806] RAC3 GAPs stimulate RAC3 GTPase activity - Canis familiaris [Reaction:R-MMU-9018806] RAC3 GAPs stimulate RAC3 GTPase activity - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-9020394] RAC3:GDP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9018804] RAC3 GEFs activate RAC3 - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9018806
summation	[Summation:9692314] The following GTPase activating proteins (GAPs) were shown t...

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(hasEvent)

[Pathway:R-HSA-9013423] RAC3 GTPase cycle

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