Reactome | PDE12 cleaves 2'-5' oligoadenylates

Schema > Depolymerisation > Entries

PDE12 cleaves 2'-5' oligoadenylates Show undefined attributes

authored	[InstanceEdit:8983763] Shamovsky, Veronica, 2017-03-27
catalystActivity	[CatalystActivity:9009951] oligoribonucleotidase activity of PDE12 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9009930] Shamovsky, Veronica, 2017-06-23
dbId	9009950
displayName	PDE12 cleaves 2'-5' oligoadenylates
edited	[InstanceEdit:9615065] Shamovsky, Veronica, 2018-07-31
eventOf	[Pathway:R-HSA-8983711] OAS antiviral response - Homo sapiens
input	[Polymer:R-HSA-8983696] 2'-5' oligoadenylate [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9009954] Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon [LiteratureReference:9009975] The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	PDE12 cleaves 2'-5' oligoadenylates
orthologousEvent	[Depolymerisation:R-CEL-9009950] PDE12 cleaves 2'-5' oligoadenylates - Caenorhabditis elegans [Depolymerisation:R-DME-9009950] PDE12 cleaves 2'-5' oligoadenylates - Drosophila melanogaster [Depolymerisation:R-GGA-9009950] PDE12 cleaves 2'-5' oligoadenylates - Gallus gallus [Depolymerisation:R-SSC-9009950] PDE12 cleaves 2'-5' oligoadenylates - Sus scrofa [Depolymerisation:R-BTA-9009950] PDE12 cleaves 2'-5' oligoadenylates - Bos taurus [Depolymerisation:R-CFA-9009950] PDE12 cleaves 2'-5' oligoadenylates - Canis familiaris [Depolymerisation:R-RNO-9009950] PDE12 cleaves 2'-5' oligoadenylates - Rattus norvegicus [Depolymerisation:R-MMU-9009950] PDE12 cleaves 2'-5' oligoadenylates - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9615280] Silverman, Robert H, 2018-07-31
schemaClass	Depolymerisation
species	[Species:48887] Homo sapiens
stId	R-HSA-9009950
summation	[Summation:9009956] Viral infection produces dsRNA that activates OAS isozymes t...

Referrals

(hasEvent)

[Pathway:R-HSA-8983711] OAS antiviral response