Reactome | MECP2 is phosphorylated at S423

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MECP2 is phosphorylated at S423 Show undefined attributes

authored	[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
catalystActivity	[CatalystActivity:9007009] calmodulin-dependent protein kinase activity of Active CaMK IV,(CaMK II) [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9006993] Orlic-Milacic, Marija, 2017-05-25
dbId	9006992
displayName	MECP2 is phosphorylated at S423
edited	[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
eventOf	[Pathway:R-HSA-9022692] Regulation of MECP2 expression and activity - Homo sapiens
inferredFrom	[Reaction:R-MMU-9007015] Mecp2 is phosphorylated at S421 - Mus musculus
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-HSA-9005549] MECP2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9006983] Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function [LiteratureReference:9017356] Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MECP2 is phosphorylated at S423
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-HSA-9007002] p-S423-MECP2 [nucleoplasm]
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07 [InstanceEdit:9608114] Christodoulou, John, 2018-08-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9006992
summation	[Summation:9006986] In resting neurons, MECP2 is phosphorylated at serine residu...

Referrals

(hasEvent)	[Pathway:R-HSA-9022692] Regulation of MECP2 expression and activity
(inferredTo)	[Reaction:R-MMU-9007015] Mecp2 is phosphorylated at S421