Reactome | IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

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IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 Show undefined attributes

authored	[InstanceEdit:8982160] Duenas, Corina, 2017-03-16
catalystActivity	[CatalystActivity:9005801] transmembrane receptor protein tyrosine kinase activity of IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane]
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
dbId	8987042
displayName	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
edited	[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
eventOf	[Pathway:R-HSA-8854691] Interleukin-20 family signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8986995] IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8854697] IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9005462] Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 TYK1 and JAK1 are phosphorylated by IL22:IL22RA1:JAK1:IL10RB:TYK2 receptor complex
orthologousEvent	[BlackBoxEvent:R-GGA-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Gallus gallus [BlackBoxEvent:R-XTR-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Xenopus tropicalis [BlackBoxEvent:R-SSC-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Sus scrofa [BlackBoxEvent:R-BTA-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Bos taurus [BlackBoxEvent:R-CFA-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Canis familiaris [BlackBoxEvent:R-RNO-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Rattus norvegicus [BlackBoxEvent:R-MMU-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8987249] IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8854645] IL22:IL22RA1:JAK1 binds IL10RB:TYK2 - Homo sapiens
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9029252] Datta, Sandip K, 2017-11-15
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8987042
summation	[Summation:9005487] Inferred from rat, mouse, human :Tyrosine protein kinase JAK...

Referrals

(hasEvent)	[Pathway:R-HSA-8854691] Interleukin-20 family signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-8986995] IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA

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