Reactome | RUNX2 binds GLI2

Schema > Reaction > Entries

authored	[InstanceEdit:8986287] Orlic-Milacic, Marija, 2017-04-24
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8986287] Orlic-Milacic, Marija, 2017-04-24
dbId	8986294
displayName	RUNX2 binds GLI2
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8941284] RUNX2 regulates chondrocyte maturation - Homo sapiens
inferredFrom	[Reaction:R-MMU-8986307] Runx2 binds Gli2 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-5635055] 2p-GLI2 [nucleoplasm] [CandidateSet:R-HSA-9007751] RUNX2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8986289] Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 binds GLI2
output	[Complex:R-HSA-8986298] RUNX2:2p-GLI2 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5635841] GLI proteins are phosphorylated - Homo sapiens [BlackBoxEvent:R-HSA-9007999] RUNX2 translocates to the nucleus - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8986294
summation	[Summation:8986301] GLI2, activated in response to Indian Hedgehog (IHH) signali...

(hasEvent)	[Pathway:R-HSA-8941284] RUNX2 regulates chondrocyte maturation
(inferredTo)	[Reaction:R-MMU-8986307] Runx2 binds Gli2