Reactome | OAS3 binds viral dsRNA

Schema > Reaction > Entries

OAS3 binds viral dsRNA Show undefined attributes

authored	[InstanceEdit:8983763] Shamovsky, Veronica, 2017-03-27
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8985092] Shamovsky, Veronica, 2017-04-11
dbId	8985157
displayName	OAS3 binds viral dsRNA
edited	[InstanceEdit:9615065] Shamovsky, Veronica, 2018-07-31
eventOf	[Pathway:R-HSA-8983711] OAS antiviral response - Homo sapiens
followingEvent	[Reaction:R-HSA-8985091] OAS3 produces oligoadenylates - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1015672] OAS3 [cytosol] [DefinedSet:R-NUL-8985076] OAS3 ligand [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8985043] Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses [LiteratureReference:8985106] Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	OAS3 binds viral dsRNA
output	[Complex:R-HSA-8985156] OAS3:OAS3 ligand [cytosol]
relatedSpecies	[Species:8983661] Dengue virus [Species:8983656] West Nile virus [Species:8985057] Sindbis virus [Species:9031716] Influenza A virus
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9615280] Silverman, Robert H, 2018-07-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8985157
summation	[Summation:8985142] Viral dsRNA-activated oligoadenylate synthetase 3 (OAS3) exh...

Referrals

(hasEvent)	[Pathway:R-HSA-8983711] OAS antiviral response
(precedingEvent)	[Reaction:R-HSA-8985091] OAS3 produces oligoadenylates