Reactome | OAS2 produces oligoadenylates

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OAS2 produces oligoadenylates Show undefined attributes

authored	[InstanceEdit:8983763] Shamovsky, Veronica, 2017-03-27
catalystActivity	[CatalystActivity:8985045] 2'-5'-oligoadenylate synthetase activity of OAS2:OAS2 ligand dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8985092] Shamovsky, Veronica, 2017-04-11
dbId	8985104
displayName	OAS2 produces oligoadenylates
edited	[InstanceEdit:9615065] Shamovsky, Veronica, 2018-07-31
eventOf	[Pathway:R-HSA-8983711] OAS antiviral response - Homo sapiens
followingEvent	[Reaction:R-HSA-8985123] RNASEL binds 2'-5' oligoadenylate - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9009997] Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells [LiteratureReference:8985090] The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases
modified	[InstanceEdit:9835670] Shamovsky, Veronica, 2023-05-17
name	OAS2 produces oligoadenylates
output	[Polymer:R-HSA-8983696] 2'-5' oligoadenylate [cytosol] 2 × [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-8985097] OAS2 dimerizes - Homo sapiens
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9615280] Silverman, Robert H, 2018-07-31
schemaClass	Polymerisation
species	[Species:48887] Homo sapiens
stId	R-HSA-8985104
summation	[Summation:9009995] 2'-5'-oligoadenylate synthetase 2 (OAS2) polymerizes ATP int...

Referrals

(hasEvent)	[Pathway:R-HSA-8983711] OAS antiviral response
(precedingEvent)	[Reaction:R-HSA-8985123] RNASEL binds 2'-5' oligoadenylate

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