Reactome | RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

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RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
created	[InstanceEdit:8939244] Orlic-Milacic, Marija, 2016-09-16
dbId	8939246
displayName	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24073] regulation of myeloid cell differentiation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8938231] RUNX1:CBFB binds CREBBP - Homo sapiens [Reaction:R-HSA-8938228] RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8938251] CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP - Homo sapiens [Reaction:R-HSA-8938389] RUNX1:CBFB binds the LGALS3 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8938382] LGALS3 gene expression is stimulated by RUNX1 and RUNX2 - Homo sapiens [Reaction:R-HSA-8939054] RUNX1 binds the PRKCB gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8939066] PRKCB gene expression is stimulated by RUNX1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8938233] Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1 [LiteratureReference:8939480] Regulation of myeloid development and function by colony stimulating factors [LiteratureReference:8938376] RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors [LiteratureReference:8939485] GALECTIN-3 expression in differentiating human myeloid cells [LiteratureReference:8939060] A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
orthologousEvent	[Pathway:R-RNO-8939246] RUNX1 regulates transcription of genes involved in differentiation of myeloid cells - Rattus norvegicus [Pathway:R-CEL-8939246] RUNX1 regulates transcription of genes involved in differentiation of myeloid cells - Caenorhabditis elegans [Pathway:R-DME-8939246] RUNX1 regulates transcription of genes involved in differentiation of myeloid cells - Drosophila melanogaster [Pathway:R-GGA-8939246] RUNX1 regulates transcription of genes involved in differentiation of myeloid cells - Gallus gallus [Pathway:R-SSC-8939246] RUNX1 regulates transcription of genes involved in differentiation of myeloid cells - Sus scrofa [Pathway:R-BTA-8939246] RUNX1 regulates transcription of genes involved in differentiation of myeloid cells - Bos taurus [Pathway:R-CFA-8939246] RUNX1 regulates transcription of genes involved in differentiation of myeloid cells - Canis familiaris [Pathway:R-MMU-8939246] RUNX1 regulates transcription of genes involved in differentiation of myeloid cells - Mus musculus
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8939246
summation	[Summation:8939476] The RUNX1:CBFB complex regulates expression of genes involve...

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[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1

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