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Schema
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Pathway
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Entries
RAB geranylgeranylation
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authored
[InstanceEdit:8875338] Rothfels, Karen, 2016-06-02
created
[InstanceEdit:8873720] Rothfels, Karen, 2016-05-19
dbId
8873719
displayName
RAB geranylgeranylation
doi
10.3180/R-HSA-8873719.1
edited
[InstanceEdit:8875248] Rothfels, Karen, 2016-06-02
eventOf
[Pathway:R-HSA-597592] Post-translational protein modification - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-8870457] FarC-PTP4A2 binds RABGGTB - Homo sapiens
[Reaction:R-HSA-8870461] RABGGTA and RABGGTB bind - Homo sapiens
[Reaction:R-HSA-8870465] RGGT binds the RAB-binding subunit - Homo sapiens
[Reaction:R-HSA-8870466] RGGT:CHM binds RABs - Homo sapiens
[Reaction:R-HSA-8870469] RGGT geranylgeranylates RAB proteins - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8855098] Rab GTPases as coordinators of vesicle traffic
[LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
[LiteratureReference:8875688] Hypervariable C-terminal domain of rab proteins acts as a targeting signal
[LiteratureReference:8874657] Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins
[LiteratureReference:8874646] Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange
[LiteratureReference:6801137] Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A
[LiteratureReference:8874649] Nucleotide dependence of Rab geranylgeranylation. Rab escort protein interacts preferentially with GDP-bound Rab
[LiteratureReference:8875709] Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes
[LiteratureReference:8875704] Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy
[LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors
[LiteratureReference:8875693] Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate
[LiteratureReference:8855099] TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism
[LiteratureReference:8855100] Illuminating the functional and structural repertoire of human TBC/RABGAPs
[LiteratureReference:8874103] Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes
[LiteratureReference:8874101] Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein
[LiteratureReference:8870364] Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein
[LiteratureReference:8875710] Protein prenylation: enzymes, therapeutics, and biotechnology applications
[LiteratureReference:6801102] Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate
[LiteratureReference:8875714] Yip3 catalyses the dissociation of endosomal Rab-GDI complexes
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
RAB geranylgeranylation
orthologousEvent
[Pathway:R-PFA-8873719] RAB geranylgeranylation - Plasmodium falciparum
[Pathway:R-SCE-8873719] RAB geranylgeranylation - Saccharomyces cerevisiae
[Pathway:R-SPO-8873719] RAB geranylgeranylation - Schizosaccharomyces pombe
[Pathway:R-DDI-8873719] RAB geranylgeranylation - Dictyostelium discoideum
[Pathway:R-CEL-8873719] RAB geranylgeranylation - Caenorhabditis elegans
[Pathway:R-DME-8873719] RAB geranylgeranylation - Drosophila melanogaster
[Pathway:R-GGA-8873719] RAB geranylgeranylation - Gallus gallus
[Pathway:R-DRE-8873719] RAB geranylgeranylation - Danio rerio
[Pathway:R-BTA-8873719] RAB geranylgeranylation - Bos taurus
[Pathway:R-CFA-8873719] RAB geranylgeranylation - Canis familiaris
[Pathway:R-RNO-8873719] RAB geranylgeranylation - Rattus norvegicus
[Pathway:R-MMU-8873719] RAB geranylgeranylation - Mus musculus
releaseDate
2016-12-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933435] Palsuledesai, Charuta C, 2016-08-04
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-8873719
summation
[Summation:8875420] Human cells have more than 60 RAB proteins that are involved...
Referrals
(hasEvent)
[Pathway:R-HSA-597592] Post-translational protein modification
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