Reactome | APP gene expression

Schema > BlackBoxEvent > Entries

APP gene expression Show undefined attributes

authored	[InstanceEdit:8862798] Shah, Kavita, 2016-02-23
category	omitted
compartment	[Compartment:984] extracellular region [Compartment:7660] nucleoplasm
created	[InstanceEdit:8870713] Orlic-Milacic, Marija, 2016-05-11
dbId	8870710
disease	[Disease:8863054] Alzheimer's disease
displayName	APP gene expression
edited	[InstanceEdit:8870719] Orlic-Milacic, Marija, 2016-05-11
eventOf	[Pathway:R-HSA-8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8870711] APP gene [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8870563] Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	APP gene expression
output	[EntityWithAccessionedSequence:R-HSA-879340] APP(672-713) [extracellular region]
precedingEvent	[Reaction:R-HSA-8870628] Phosphorylated FOXO3 translocates to the nucleus - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-8870712] Positive regulation by 'p-S43,S173,S294,S325-FOXO3 [nucleoplasm]'
regulationReference	[RegulationReference:9642277] Positive regulation by 'p-S43,S173,S294,S325-FOXO3 [nucleoplasm]' Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8870710
summation	[Summation:8870717] Transcription of the APP gene is increased by FOXO3, downstr...

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[Pathway:R-HSA-8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models