Reactome | CDK5:p25 phosphorylates PRDX2

Schema > Reaction > Entries

authored	[InstanceEdit:8862798] Shah, Kavita, 2016-02-23
catalystActivity	[CatalystActivity:8863661] protein serine/threonine kinase activity of CDK5:p25 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8868576] Orlic-Milacic, Marija, 2016-04-22
dbId	8868573
disease	[Disease:8863054] Alzheimer's disease
displayName	CDK5:p25 phosphorylates PRDX2
edited	[InstanceEdit:8870548] Orlic-Milacic, Marija, 2016-05-10
eventOf	[Pathway:R-HSA-8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models - Homo sapiens
inferredFrom	[Reaction:R-MMU-8868589] Cdk5:p25 phosphorylates Prdx2 - Mus musculus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-3341292] PRDX2 [cytosol]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:8868566] Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDK5:p25 phosphorylates PRDX2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-8868574] p-T89-PRDX2 [cytosol]
precedingEvent	[Reaction:R-HSA-8863013] CDK5 binds p25 - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8868573
summation	[Summation:8868603] Oxidative stress, manifested through accumulation of reactiv...

(hasEvent)	[Pathway:R-HSA-8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
(inferredTo)	[Reaction:R-MMU-8868589] Cdk5:p25 phosphorylates Prdx2

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