Reactome | p25-bound CDK5 phosphorylates CDC25B

Schema > Reaction > Entries

authored	[InstanceEdit:8862798] Shah, Kavita, 2016-02-23
catalystActivity	[CatalystActivity:8863661] protein serine/threonine kinase activity of CDK5:p25 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8863015] Orlic-Milacic, Marija, 2016-03-02
dbId	8863007
disease	[Disease:8863054] Alzheimer's disease
displayName	p25-bound CDK5 phosphorylates CDC25B
edited	[InstanceEdit:8870548] Orlic-Milacic, Marija, 2016-05-10
eventOf	[Pathway:R-HSA-8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-157412] CDC25B [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8862800] Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p25-bound CDK5 phosphorylates CDC25B
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-8863644] p-S50,T69,S160,S321,S470-CDC25B [cytosol]
precedingEvent	[Reaction:R-HSA-8863013] CDK5 binds p25 - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8863007
summation	[Summation:8863645] CDK5, activated by binding to p25 phosphorylates CDC25B prot...

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