Reactome | MYLIP dimer ubiquitinates VLDLR on Lys-839

Schema > Reaction > Entries

MYLIP dimer ubiquitinates VLDLR on Lys-839 Show undefined attributes

authored	[InstanceEdit:8854629] Jassal, Bijay, 2016-01-28
catalystActivity	[CatalystActivity:8855139] ubiquitin protein ligase activity of MYLIP dimer [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:8854629] Jassal, Bijay, 2016-01-28
dbId	8854628
displayName	MYLIP dimer ubiquitinates VLDLR on Lys-839
edited	[InstanceEdit:8854629] Jassal, Bijay, 2016-01-28
eventOf	[Pathway:R-HSA-8866427] VLDLR internalisation and degradation - Homo sapiens
input	3 × [DefinedSet:R-HSA-450143] K63-Ub [cytosol] [EntityWithAccessionedSequence:R-HSA-5216079] VLDLR [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854961] The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2 [LiteratureReference:8854975] Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor [LiteratureReference:8854977] Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis [LiteratureReference:8855264] LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor [LiteratureReference:9765100] Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL)
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	MYLIP dimer ubiquitinates VLDLR on Lys-839
orthologousEvent	[Reaction:R-DME-8854628] MYLIP dimer ubiquitinates VLDLR on Lys-839 - Drosophila melanogaster [Reaction:R-GGA-8854628] MYLIP dimer ubiquitinates VLDLR on Lys-839 - Gallus gallus [Reaction:R-SSC-8854628] MYLIP dimer ubiquitinates VLDLR on Lys-839 - Sus scrofa [Reaction:R-BTA-8854628] MYLIP dimer ubiquitinates VLDLR on Lys-839 - Bos taurus [Reaction:R-CFA-8854628] MYLIP dimer ubiquitinates VLDLR on Lys-839 - Canis familiaris [Reaction:R-RNO-8854628] MYLIP dimer ubiquitinates VLDLR on Lys-839 - Rattus norvegicus [Reaction:R-MMU-8854628] MYLIP dimer ubiquitinates VLDLR on Lys-839 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8855136] Ub-K839-VLDLR [plasma membrane]
regulatedBy	[PositiveRegulation:R-HSA-8854956] Positive regulation by 'NR1H2,NR1H3 [nucleoplasm]'
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8866933] D'Eustachio, Peter, 2016-04-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8854628
summation	[Summation:8854959] The E3 ubiquitin-protein ligase (MYLIP, aka IDOL) mediates t...

Referrals

(hasEvent)

[Pathway:R-HSA-8866427] VLDLR internalisation and degradation