Reactome | FGFR3 fusions dimerize

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FGFR3 fusions dimerize Show undefined attributes

authored	[InstanceEdit:8851715] Rothfels, Karen, 2016-01-08
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8853327] Rothfels, Karen, 2016-01-22
dbId	8853317
disease	[Disease:1500689] cancer
displayName	FGFR3 fusions dimerize
edited	[InstanceEdit:8851715] Rothfels, Karen, 2016-01-08
entityFunctionalStatus	[EntityFunctionalStatus:8853291] gain_of_function of FGFR3 fusions [plasma membrane]
eventOf	[Pathway:R-HSA-8853334] Signaling by FGFR3 fusions in cancer - Homo sapiens
followingEvent	[Reaction:R-HSA-8853309] Autocatalytic phosphorylation of FGFR3 fusions - Homo sapiens
input	2 × [DefinedSet:R-HSA-8853269] FGFR3 fusions [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8853053] Transforming fusions of FGFR and TACC genes in human glioblastoma [LiteratureReference:8852986] Oncogenic FGFR3 gene fusions in bladder cancer [LiteratureReference:8852972] Identification of targetable FGFR gene fusions in diverse cancers [LiteratureReference:8852927] FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer [LiteratureReference:8852962] Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma [LiteratureReference:8852989] Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma [LiteratureReference:8852935] FGFR3-TACC3: A novel gene fusion in cervical cancer [LiteratureReference:8852916] Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours [LiteratureReference:8852905] Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly [LiteratureReference:8853033] The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma [LiteratureReference:8852997] TACC3 protein regulates microtubule nucleation by affecting ?-tubulin ring complexes
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FGFR3 fusions dimerize
output	[DefinedSet:R-HSA-8853268] FGFR3 fusion dimers [plasma membrane]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8853855] Grose, Richard P, 2016-01-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8853317
summation	[Summation:8853083] Constitutively active fusions of FGFR3 have been identified ...

Referrals

(precedingEvent)	[Reaction:R-HSA-8853309] Autocatalytic phosphorylation of FGFR3 fusions
(hasEvent)	[Pathway:R-HSA-8853334] Signaling by FGFR3 fusions in cancer