Reactome | ACAT2 condenses 2 Ac-CoA to form ACA-CoA

Schema > Reaction > Entries

ACAT2 condenses 2 Ac-CoA to form ACA-CoA Show undefined attributes

authored	[InstanceEdit:8848214] Jassal, Bijay, 2015-12-07
catalystActivity	[CatalystActivity:8848220] acetyl-CoA C-acetyltransferase activity of ACAT2 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8848214] Jassal, Bijay, 2015-12-07
crossReference	[DatabaseIdentifier:11880901] Rhea:21037
dbId	8848215
displayName	ACAT2 condenses 2 Ac-CoA to form ACA-CoA
edited	[InstanceEdit:8848214] Jassal, Bijay, 2015-12-07
eventOf	[Pathway:R-HSA-191273] Cholesterol biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Homo sapiens
input	2 × [SimpleEntity:R-ALL-76183] Ac-CoA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8848229] Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase [LiteratureReference:8848228] Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	ACAT2 condenses 2 Ac-CoA to form ACA-CoA
orthologousEvent	[Reaction:R-PFA-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Plasmodium falciparum [Reaction:R-SCE-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Saccharomyces cerevisiae [Reaction:R-SPO-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Schizosaccharomyces pombe [Reaction:R-DDI-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Dictyostelium discoideum [Reaction:R-DME-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Drosophila melanogaster [Reaction:R-GGA-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Gallus gallus [Reaction:R-XTR-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Xenopus tropicalis [Reaction:R-DRE-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Danio rerio [Reaction:R-SSC-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Sus scrofa [Reaction:R-BTA-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Bos taurus [Reaction:R-CFA-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Canis familiaris [Reaction:R-RNO-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Rattus norvegicus [Reaction:R-MMU-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Mus musculus
output	[SimpleEntity:R-ALL-191293] ACA-CoA [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-HSA-75848] ACLY tetramer transforms CIT to Ac-CoA - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8866933] D'Eustachio, Peter, 2016-04-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8848215
summation	[Summation:8848223] Three human enzymes can utilise ketone bodies for energy pro...

Referrals

(hasEvent)	[Pathway:R-HSA-191273] Cholesterol biosynthesis
(precedingEvent)	[Reaction:R-HSA-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA