Reactome | NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9009086] Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9625735] FOXO1:NR3C1:(ALDO,11DCORST,CORST,CORT):TRIM63 gene [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9009085] DEXA:NR3C1 complex binds RUNX2 gene proximal promoter - Homo sapiens [Reaction:R-HSA-9769347] Activated glucocorticoid receptor binds NPAS4 gene promoter - Homo sapiens [Reaction:R-HSA-8856930] EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene - Homo sapiens [Reaction:R-HSA-4341025] SUMOylation of NR3C1 (GR) with SUMO1 - Homo sapiens [Reaction:R-HSA-9625699] FOXO1 and NR3C1 bind TRIM63 gene promoter - Homo sapiens
created	[InstanceEdit:879815] May, B, 2010-06-23
dbId	879850
displayName	NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
hasComponent	2 × [Complex:R-HSA-9625947] NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-879850] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] - Mus musculus [Complex:R-RNO-879850] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-879850] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] - Canis familiaris [Complex:R-BTA-879850] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] - Bos taurus [Complex:R-SSC-879850] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] - Sus scrofa [Complex:R-DRE-879850] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] - Danio rerio [Complex:R-XTR-879850] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-879850] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] - Gallus gallus [Complex:R-DME-879850] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] - Drosophila melanogaster
isChimeric	false
modified	[InstanceEdit:9625967] Orlic-Milacic, Marija, 2018-10-23
name	NR3C1:(ALDO,11DCORST,CORST,CORT) dimer Glucocorticoid receptor:Glucocorticoid ligand complex dimer GR:Glucocorticoid ligand dimer
positivelyRegulates	[PositiveGeneExpressionRegulation:R-HSA-879832] Positive gene expression regulation by 'NR3C1:Dexamethasone [nucleoplasm]'
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-879850

(input)	[Reaction:R-HSA-4341025] SUMOylation of NR3C1 (GR) with SUMO1 [Reaction:R-HSA-9625699] FOXO1 and NR3C1 bind TRIM63 gene promoter [Reaction:R-HSA-9009085] DEXA:NR3C1 complex binds RUNX2 gene proximal promoter [Reaction:R-HSA-9769347] Activated glucocorticoid receptor binds NPAS4 gene promoter [Reaction:R-HSA-8856930] EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene
(regulator)	[PositiveGeneExpressionRegulation:R-HSA-879832] Positive gene expression regulation by 'NR3C1:Dexamethasone [nucleoplasm]'
(hasComponent)	[Complex:R-HSA-9625735] FOXO1:NR3C1:(ALDO,11DCORST,CORST,CORT):TRIM63 gene [nucleoplasm] [Complex:R-HSA-9009086] Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm] [Complex:R-HSA-9769707] NR3C1:(ALDO,11DCORST,CORST,CORT) dimer:NPAS4 gene [nucleoplasm] [Complex:R-HSA-8856931] PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm]
(activeUnit)	[PositiveGeneExpressionRegulation:9625742] Positive gene expression regulation by 'FOXO1:NR3C1:(ALDO,11DCORST,CORST,CORT):TRIM63 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-9009100] Negative gene expression regulation by 'Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9769721] Negative gene expression regulation by 'NR3C1:(ALDO,11DCORST,CORST,CORT) dimer:NPAS4 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8856938] Positive gene expression regulation by 'PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm]'

NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] Show undefined attributes

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